Prof. Dr. Khadiga Ismail

Dean of the Faculty of Pharmacy

Biography

– Khadiga Ahmed Ismail, Professor, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt since 2002.

–  A scholarship for post-doctoral studies at OSU, Columbus, Ohio, USA during 1999 –2000.

–  Professor visitor at Beirut Arab University, 1998, 2002 and 2004.

–  Professor visitor at Oman Pharmacy Institute, 2008 and 2011.

– Professor, Department of Medicinal Chemistry, Faculty of Pharmacy, King Abd Al Aziz University, Jeddah, Saudi Arabia, 2002-2004, 2006-2008 and 2012 – 2015.

– Vice dean of student affairs and Head of pharmaceutical chemistry department, Faculty of Pharmacy, University of Alexandria, 2016 -2017.

– Dean of Faculty of Pharmacy, University of Alexandria, 10/2017- till 9/2020.

– Dean of Faculty of Pharmacy, Alamein International University, from 10/ 2020 till now.

 

 

  • Supervising the practical courses of organic chemistry for undergraduate students.
  • Lecturing theoretical courses of organic chemistry for undergraduate students.
  • Lecturing theoretical courses of advanced organic chemistry and synthetic organic chemistry for graduate students.
  • Discovery of a novel DNA binding agent via design and synthesis of new thiazole hybrids and fused 1,2,4-triazines as potential antitumor agents: Computational, spectrometric and in silico studies.

Marwa H. El-Wakil, Amira F. El-Yazbi , Hayam M.A. Ashour, Mounir A. Khalil, Khadiga A. Ismail , Ibrahim M. Labouta , Bioorganic Chemistry 90 (2019) 103089

  • Synthesis, Estrogenic And Antiestrogenic Activities of Some Triarylpyrazole Derivatives.

Mahmoud A. Ragab, Heba A. Abd El Razik, Elham A. Afify, Khadiga A. Ismail, Mounir A. Khalil, Nargues S. Habib, Med. Chem. Res. 2017, 26, 2785–2808.

  • Synthesis, biological evaluation and molecular docking studies of some pyridine derivatives.

Ahmed M. Fargualy, Nargues S. Habib, Khadiga A. Ismail, Ahmed M.M. Hassan, Marwa T.M. sag. Eur. J. Med. Chem, 2013, Vol.66, p. 276-295

  • Synthesis of some (E)-6-[2-(furan-2-yl)ethenyl]-1,2,4-triazin-5-ones and their biological evaluation as antitumor agents

Hayam M.Ashour, Marwa H. Elwakil, Mounir A. Kalil, Khadiga A. Ismail, Ibrahim M. Labouta. Med. Chem. Res., 2013, Vol. 22, Issue4, p. 1909-1924

  • Synthesis of some heterocycles attached or fused to phthalazine ring system of possible antihypertensive activity.

N.S. Habib, A.M. Farghaly,F A Ashour, Khadiga A. Ismail, H.A. Abd El Razik and A. Nour El Din. Bollettino Chimico Farmaceutico 2006

  • Synthesis of some heterocycles attached or fused to phthalazine ring system for their antimicrobial and anticancer activities.

N.S. Habib, A.M. Farghaly,F A Ashour, Khadiga A. Ismail, H.A. Abd El Razik and A. Nour El Din. Boll. Chim. Farmac., 145, 2, 2005

  • Part 2: Synthesis of antagonists to the alpha3beta4* nicotinic acetylcholine receptors through modifications to the ester.Bergmeier SC,

Ismail KA, Arason KM, McKay S, Bryant DL, McKay DB: Structure activity studies of ring E analogues of methyllycaconitine. Bioorg Med Chem Lett; 2004 Jul 16;14(14):3739-42

  • Pyrimidines Part II : Synthesis of novel pyrimidines, 1,2,4-triazolo [4,3-a]pyrimidin-7-ones and pyrimidino[2,1-c][1,2,4]triazin-8-ones for their antimicrobial and anticancer activities.

N.S. Habib, R. Soliman, Khadiga A. Ismail, A.M. Hassan and M.T. Sarg. Boll. Chim. Farmac., 142, 9 (2003)

  • Synthesis of novel pyrimidine 2,4-diones and 2-thioxopyrimidine-4-ones as potential anticancer and antimicrobial agents.

Soliman, N.S. Habib, Khadiga A. Ismail, A. Moustafa, M.T. Sarg and N.H. Fanaki. Boll. Chim. Farmac., 142- 4 (2003).

  • Effects of methyllycaconitine and related analogues on bovine adrenal alpha3beta4* nicotinic acetylcholine receptors.

Bryant DL, Free RB, Thomasy SM, Lapinsky DJ,Ismail KA, Arason KM, Bergmeier SC, McKay DB. Ann N Y Acad Sci; Oct ; 971, 139 – 141(2002)

  • Structure-activity studies with ring E analoge of methyllcaconitine on bovine adrenal a3 b4 nicotinic receptor

Darrall L. Bryant. R. Benjammin Free Sara M. Thomasy, Darid J. Lapinsky, Khadiga A. Ismail, Susan B. Mckay. Neuroscience Research, 42, 57-63 (2002)

  • Structure-activity studies with ring E analogues of methyllycaconitine. Synthesis and evaluation of enantiopure isomers of selective antagonist at the alpha3 nicotinic receptor.

Ismail KA, Bergmeier SC. Eur J Med Chem; Jun;37(6):469-74(2002) Presented in the 9th Cyprus Conference on New Method in Drug Research, Limassol, Cyprus 17-22 May 2001.

  • Structure-activity studies on N-(3-phenyl)-propyl)piperidine derivatives of methyllycaconitine on nicotinic receptor subtypes :

D.L. Bryant, S.C. Bergmeier, Khadiga A. Ismail, S.M. Thomasy, G.W. Danial, D.B. Mckay. Presented in part at the 30th Annual Meeting of The Society For Neuroscience, New Orieans, LA, November 4-9, 2000.

  • Structure-activity studies with ring E analoge of methyllycaconitine. II Substitution on the imide ring.

Khadiga A. Ismail, S.C. Beergmeier, D.L. Bryant. Presented in the 9th Cyprus Conference on New Method in Drug Research, Limassol, Cyprus 17-22 May 2001

  • Synthesis and biological evaluation of some novel 4H-benzopyran-4-one derivatives as nonsteroidal antiestrogens :

Khadiga A. Ismail, Abd El Aziem T. Eur. J. Med. Chem., 36, 243 (2001).

  • Novel triazolo[4,3-a]quinazolines and bis-triazolo[4,3-a:4,3`-c] quinazolines : Synthesis and antioxo-plasmosis effect :

Alaa A. El-Tombary, Khadiga A. Ismail, Omaima M. Aboul Wafa, A,-Mohsen M.E. Omar, Mervat Z. El-Azzouni and Salwa T. El-Mansoury, IL Farmaco 54, 486-495 (1999)

  • Antilipidemic agents, Part IV; Synthesis and Antilipidemic testing of some heterocyclic derivatives of hexadecyl and cyclohexyl hemi-succinate esters :

N.S. Habib, Khadiga A. Ismail, A.A. Tombary and T. Abdel Aziem, Pharmazie 55, 495 (2000).

  • Synthesis of monosubstituted succinic acids from tert-butylsuccinate :

Stephen C. Bergmeier and Khadiga A. Ismail. Synthesis 10, 1369 (2000).

  • Synthesis of 9-{4-[2-(substituted amino)ethoxy]-phenoxy}2-methoxy-acridine as potential antimicrobial and antitumor agents :

Khadiga A. Ismail and Tarek Abd El Aziem, Alex. J. Pharm. Sci., 14(2), 161 (2000).

  • Synthesis and antimicrobial activity of some quinoxaline derivatives. The cyclodesulfurization of thio-compounds : Part XXVI :

Alaa A. El-Tombary, Khadiga A. Ismail, Omaima M. Aboul Wafa and Essam A. Koreish, Alex. J. Pharm. Sci., 12, 27 (1998)

  • Novel steroidal 1,4-diketone and pyridazine derivatives as potential antiestrogens

Khadiga A. Ismail, Alaa A. El-Tombary, M. Aboul Wafa, A.-Mohsen, M.E. Omar and Safaa H. El Reyini, Presented at the International Conference of Pharmaceutical Sciences and Technology, held in Alexandria, Egypt, on March 22-25, 1995, Arch. Pharm. Med. Chem., 329, 433 (1996).

 

  • Synthesis of novel estradiol thiosemicarbazone derivatives as potential antiestrogens.

Alaa A. El-Tombary, Khadiga A. Ismail, Omaima M. Aboul Wafa, A.-Mohsen, M.E. Omar and Safaa H. El Reyini, Presented at the International Conference of Pharmaceutical Sciences and Technology, held in Alexandria, Egypt, on March 22-25, Alex. J. Pharm. Sci., 9(2), 147 (1995).

  • Synthesis and antimicrobial activity of some tetramethylenethieno [2,3-d]pyrimidine derivative.

Khadiga A. Ismail, Omaima A. Aboul Wafa, Essam A. Koreish, IL Farmaco, 50(9), 611 (1995)

  • Synthesis and biological evaluation of some novel 2-(pyrimidin-4-yl) estradiol derivatives.

Khadiga A. Ismail, Alaa A. El-Tombary, A.-Mohsen M.E. Omar, Omaima M. Aboul Wafa, Naglaa I. Madi, Eur. J. Med. Chem., 30, 423 (1995)

  • Synthesis and unterotrophic activity of 2-substituted estradiol and ring A. Fused pyranone and furanone derivatives.

Khadiga A. Ismail and Azza El-Medany, Alex. J. Pharm. Sci., 8(2), 95 (1994).

  • Synthesis of 3-arylamino-1,2,4-triazolo[3,4-c]pyrimidino[4,5-b]tetra-hydrobenzothiophenes by cyclodesulfurization of the corresponding thiocarbamoylhydrazinothieno[2,3-d]pyrimidine Derivatives.

Khadiga A. Ismail and Omaima M. ABoul Wafa, Sulfer Letters, 15(3), 111 (1992).

  • Synthesis and antimicrobial activity of some thiazolinyl tetrahyrobenzo [b]thiophenes and thiazolinyl tetrahydrobenzothieno[2,3-d]pyrimidine-4-ones.

Omaima M. Aboul Wafa, Khadiga A. Ismail and Essam A. Koreish. IL Farmaco, 47(5), 631 (1992).

  • Synthesis, binding affinities and uterotrophic activity of some 2-substituted estradiol and ring A-fused pyrone derivatives.

A.-Mohsen M.E. Omar, I. C. Ahmed, Omaima M. Aboul Wafa, Ahmed M.M. Hassan, Khadiga A. Ismail and Hamida Abou-Shleib. Eur. J. Med. Chem. 29, 25 (1994).

  • Synthesis and evaluation for antimicrobial and antifungal activities of new 1-phenylhydrazono-2-(substituted thiocarbamoyl)hydrazono-pyruvaldehyde and the corresponding thiazoline and thiazolidinone derivatives.

A.-Mohsen M.E. Omar, Ibrahim C. Ahmed, Ahmed M.M. Hassan, Omaima M. Aboul Wafa, Hamida Abou-Shleib and Khadiga A. Ismail. Alex. J. Pharm. Sci., 4(2), 182 (1990).

  • Synthesis and evaluation for Antimicrobial and antifungal activities of new 5-dimethylamino-1-aryl [and 1-(2-furyl)]-1-penten-3-one-3-substituted thiosemicarbazone derivatives.

A.-Mohsen M.E. Omar, I. Chaaban, Ahmed M.M. Hassan, Omaima M. Aboul Wafa, Hamida Abou-Shleib and Khadiga A. Ismail. Alex. J. Pharm. Sci., III (2), 244 (1989).

  • Novel thiosemicarbazone, thiazolines and thiazolidinones derived from chalcones : Synthesis, antimicrobial and anticancer properties.

A.-Mohsen M.E. Omar, I. Chaaban, Omaima M. Aboul Wafa, Ahmed M.M. Hassan, Hamida Abou-Shleib and Khadiga A. Ismail. Alex. J. Pharm. Sci., III (2), 211 (1989).

  • Synthesis and evaluation of antitumor and antimicrobial activities of 4-phenyl-2-oxo-3-butenal-1,2-bisthiosemicarbazone derivatives.

A.-Mohsen M.E. Omar, I. Chaaban, Ahmed M.M. Hassan, Khadiga A. Ismail and Hamida Abou-Shleib, Alex. J. Pharm. Sci., 1, 17 (1987).

  • First Anglo-Egyptian Conference of Pharmaceutical Sciences, Sheraton-Montazah, November 15-17, 1988, Alexandria-Egypt.
  • Second Anglo-Egyptian Conference of Pharmaceutical Palestine-Hotel-Montazah, November 9-12, 1991, Alexandria-Egypt.
  • The International Conference of Pharmaceutical Sciences and Technology, Palestine-Hotel, Montazah, March, 22-25, 1995, Alexandria-Egypt.
  • The 6th Ibn-Sina International Conference on Pure and Applied Heterocyclic Chemistry, Cairo, Egypt, December 13-16/1997.
  • The 9th Cyprus Conference on New Methods in Drug Research, Limasol, Cyprus, May 17-22, 2001.
  • Fifth Scientific Forum for KAU student, King Abd Al Aziz University, December 10-12/2013
  • “Ninth Forum Academic Output for academic year 2014”. Center for teaching and     learning development, King Abd Al Aziz University, February 6/2014.
  • International conference on Pharmaceutical and Healthcare Sciences, Helton Green Plaza, Alexandria, Egypt, November 6-7/2019.

Google Scholar Profile
https://scholar.google.com.eg/citations?user=8OBhsZ0AAAAJ&hl=en