Assoc. Prof. Dr. Hanan Ragab

Associate Professor
Department of Medicinal Chemistry

Biography

Faculty Appointments:

  • Vice deputy, Quality Assurance Unit, Faculty of Pharmacy, University of Alexandria, Egypt.
  • 2019, Member of the organizing committee of PHS2019 conference, Faculty of Pharmacy, University of Alexandria, Egypt.

Areas of Expertise:

• Research Activities (Faculty of Pharmacy at Alexandria University, Virginia commonwealth University and Beirut Arab University):

Design, synthesis and in vitro/in vivo evaluation of new pharmacologically active compounds including: Acetyl Cholinesterase Inhibitors, Nicotinic Receptor Ligands, Antiinflammatory and analgesic drugs, Anticancer drugs, Antimicrobial agents and Antimalarial agents.

• Teaching Activities (Faculty of Pharmacy at Alexandria University, Damanhur University, Arab Academy for Science, Technology & Maritime Transport, Kafr El Sheikh University and Beirut Arab University):

Teaching of Practical and Theoretical Pharmaceutical Organic Chemistry courses for undergraduate students as well as continuing education courses for medical professions and postgraduate courses.

  • 2019-present, Associate professor,Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt.
  • 2014 – 2019, Lecturer, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt.
  • 2011 – 2014, Assistant Professor, Department of Pharmaceutical Chemistry, Faculty of Pharmacy,  Beirut Arab University, Beirut 11072809, Lebanon.
  • 2007 – 2011, Lecturer, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria21521, Egypt.
  • 2003 – 2007, Assistant Lecturer, Department of Pharmaceutical Chemistry, Faculty of Pharmacy,  University of Alexandria, Alexandria21521, Egypt.
  • 2000 – 2003, Demonstrator (Teaching Assistant), Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria21521, Egypt
  • 2019, member of the organizing committee of PHS2019 conference, Faculty of Pharmacy,
    University of Alexandria, Alexandria 21521, Egypt.
  • 2016 – present, member of the community committee, Faculty of Pharmacy, University of
    Alexandria, Alexandria 21521, Egypt.
  • 2015 – 2018, vice deputy, Quality Assurance Unit, Faculty of Pharmacy, University of
    Alexandria, Alexandria 21521, Egypt.

Alexandria University:

  • Teaching of Practical and Theoretical Pharmaceutical Organic Chemistry courses for undergraduate students as well as continuing education courses for medical professions.
  • Teaching Spectroscopic Identification of Pharmaceutical Compounds course (0905601) for postgraduate “Drug Design, Synthesis & Quality Control” Diploma, Alexandria University, Egypt.
  • Teaching Selected Topics in Advanced Organic Chemistry Course (0905801) for postgraduate “Drug Design, Synthesis & Quality Control” Diploma, Alexandria University, Egypt.
  • Teaching Seminar I courses for postgraduate program students, Alexandria University, Egypt.

Beirut Arab University (2011-2014):

  • Teaching of Practical and Theoretical Pharmaceutical Organic Chemistry, Pharmaceutical Chemistry, Medicinal Chemistry courses for undergraduate students as well as continuing education courses for medical professions.
  • Teaching Theoretical course on Drug Library and Literature Surveying for postgraduate students.

College of Pharmacy, Arab Academy for Science, Technology & Maritime Transport (2016/2017):

  • Teaching of Practical and Theoretical Pharmaceutical Organic Chemistry courses for undergraduate students.

Faculty of Pharmacy, Damanhour University (2009-2011, 2014-2020)

  • Teaching of Practical and Theoretical Pharmaceutical Organic Chemistry courses for undergraduate students.

Faculty of Pharmacy, Kafr El Sheikh University (2019-2021)

  • Teaching of Practical and Theoretical Pharmaceutical Organic Chemistry courses for undergraduate students.
  • Teaching Selected Topics in Advanced Organic Chemistry Course for postgraduate students.

Faculty of Pharmacy, Alamein international University (2021/2022)

  • Teaching of Practical and Theoretical Pharmaceutical Organic Chemistry courses for undergraduate students.

1. Aryloxyethylamines: Binding at 7 Nicotinic Acetylcholine Receptors. Hanan M. Ragab, Jin Sung Kim, MalgorzataDukat, Herna’n Navarro and Richard A. Glennon, Bioorg med chemlett, 16, 4283 (2006).

2. Design, Synthesis and Biological Screening of Some Pyridinylpyrazole and Pyridinylisoxasole Derivatives as Potential Anti-Inflammatory, Analgesic, Antipyretic and Antimicrobial Agents. Soad A.M. El-Hawash, RaafatSoliman, Amal M. Youssef, Hanan M.A. Ragab, Perihan A.S. Elzahhar, Ibrahim M. El-Ashmawey, Abeer E. Abdel Wahab and Iman A Shaat., Med Chem, 10(3), 318 (2014).

3. Design, Synthesis and Antimicrobial Evaluation of Methyl Pyridyl-2,4-Dioxobutanoates and Some New Derived Ring Systems. Perihan A.S. Elzahhar, RaafatSoliman, Soad A.M. El-Hawash,Hanan M.A. Ragab, Amal M. Youssef, Abeer E. Abdel Wahab, Med Chem, 11(4), 407 (2015).

4. Synthesis and biological evaluation of some tacrine analogs: study of the effect of the chloro substituent on the acetylcholinesterase inhibitory activity. Hanan M. Ragab, Hayam M.A. Ashour, Amal Galal, Asser I. Ghoneim, Hassan R. Haidar, MonatshChem, 147, 539 (2016)

5. Synthesis of some new amide-linked bipyrazoles and their evaluation as anti-inflammatory and analgesic agents. Wissam H. Faour, Mohamed Mroueh, Costatantine F. Daher, Rasha Y. Elbayaa, Hanan M. Ragab, Asser I. Ghoneim, Ahmed I. El-Mallah, Hayam M.A. Ashour, J EnzInhib Med Chem,
31(6), 1079 (2016).

6. Compounds containing azole scaffolds as Cyclooxygenase inhibitors: A review. Hanan M.A. Ragab, Adnan A. Bekhit, Sherif A.F. Rostom and Alaa El-Din A. Bekhit,Current topics in Medicinal Chemistry, 16(30), 3569 (2016).

7. Synthesis of new pyrazolo[3,4-d]pyrimidine derivatives and evaluation of their anti-inflammatory and anticancer activities. Heba A. Abd El Razik, Mohamed Mroueh, Wissam H. Faour, Wassim N. Shebaby, Costantine F. Daher, Hayam M.A. Ashour, Hanan M. Ragab, ChemBiol Drug Des, 90, 83 (2017).

8. Pyrazolylpyrazolines: design, synthesis and biological evaluation as dualacting antimalarialantileishmanial agents. Adnan Bekhit, EskedarLodebo, AriayaHymete, HananRagab, Alaa ElDin Bekhit, International Journal of Pharmacological And Pharmaceutical Sciences, 4(1), 2017.

9. Investigation of chronic efficacy and safety profile of two potential anti-inflammatory bipyrazole-based compounds in experimental animals. S Domiati, M Mehanna, H Ragab, HN Chmaisse, A El Mallah, Journal of Inflammation Research, 11, 143(2018)

10. Elucidation of the molecular mechanism underlying the anti-inflammatory activity of an effective and safe bipyrazole-based compound.S Domiati, M Mehanna, H Ragab, KH Abd El Galil, HN Chmaisse, A El Mallah, Inflammation Research, 68, 379(2019)

11. Chlorinated tacrine analogs: Design, synthesis and biological evaluation of their anti-cholinesterase  activity as potential treatment for Alzheimer’s disease. Hanan.M. Ragab, Mohamed Teleb, Hassan R. Haidar and Noha Gouda, Bioorg. Chem, 86, 557-568 (2019).

12. Synthesis, biological evaluation and modeling of hybrids from tetrahydro-1H-pyrazolo[3,4-b]quinolines as dual cholinestrase and COX-2 inhibitors. Mohamed Mroueh, Wissam H. Faour, Wassim N. Shebaby, Costantine F. Daher,Tamer M. Ibrahimd, Hanan M. Ragab, Bioorg. Chem, 100, 103895 (2020).

13. Design, synthesis, biological evaluation and in silico studies of certain aryl sulfonyl hydrazones  conjugated with 1,3-diaryl pyrazoles as potent metallo-β-lactamase inhibitors. Marwa M. Shaaban, Hanan M. Ragab, Kenichi Akaji, Ross P. McGeary, Alaa-Eldin A. Bekhit, Waleed M. Hussein, Julia L. Kurz, Bassma H. Elwakil, Salma A. Bekhit, Tamer M. Ibrahim, Mona A Mahran, Adnan A. Bekhit. Bioorg. Chem, 105, 104386 (2020).

1. Aryloxyethylamines: Binding at 7 Nicotinic Acetylcholine Receptor. Hanan M. Ragab, Jin Sung Kim,  MalgorzataDukat, Herna’n Navarro and Richard A. Glennon,, 84th Annual Meeting of the Virginia Academy of Science, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA, 25-26th May, 2006, Abst. P58.

2. Anabaseing Analogues: Binding at 7 Nicotinic Acetylcholine Receptors . Jin Sung Kim, Hanan M. Ragab, MalgorzataDukat, Herna’n Navarro and Richard A. Glennon,, 20th LAAS International Science Conference entitled Advanced Research for Better Tomorrow, The Lebanese Association for The Advancement of Science in Collaboration with Doctoral School of Science And Technology at The Lebanese University, Al Hadath, Lebanon, 27-29th March, 2014.

3. Synthesis of Some NewAmide-linked Bipyrazoles and Their Evaluation as Antiinflammatory, Analgesic and Antimicrobial agents. H.M. Ashour, R.Y. Elbayaa, H. M. Ragab, A. I. Ghoneim, M.Mroueh, W. Faour and R. Ramadan,3rd International Conference of Organic Chemistry, 25-28th September, 2014,Tibilisi, Georgia,Abst. PP62 (page 235).

4. Novel Chlorinated Tacrine-Related Analogs As Potential Candidates for The Treatment of Alzheimer Disease,H. M. Ragab, H.M. Ashour, A. Galal,A. I. Ghoneim, H.R. Haidar, 13th Ibn Sina International Conference on Pure and Applied Heterocyclic Chemistry, Hurgada, Egypt, 14-17th February, 2015, PP59.

5. Quinuclidine Containing Analogues: Binding At 7 Nicotinic Cholinergic Receptors As Potential Treatment of Alzheimer Disease. Hanan M. Ragab, MalgorzataDukat, Herna’n Navarro and Richard A. Glennon,  13th Ibn Sina International Conference on Pure and Applied Heterocyclic Chemistry,Hurgada, Egypt, 14-17th February, 2015, PP60.

6. Pyrazolylpyrazolines: Design, Synthesis And Biological Evaluation As Dual Acting AntimalarialAntileishmanial Agents. Adnan Bekhit, EskedarLodebo, AriayaHymete, HananRagab, Alaa ElDin Bekhit, 19th International Conference on Medicinal Chemistry and Biopharmaceutics, Word Academy of Science Engineering And Technology, London, England, 19-20 January, 2017, p1171.

7. Synthesis and Biological Evaluation of Some Heterocyclic Compounds as -lactamase Inhibitors. Adnan Bekhit,Mona A. Mahran, Kenichi Akaji, Hanan.M. Ragab, Marwa M. Shaaban, Nano Chemistry Conference, Faculty of Science, Alexandria, Egypt, 29 July, 2017, 12A.

8. Chlorinated tacrine analogs: Design, synthesis and biological evaluation of their anti-cholinesterase activity as potential treatment for Alzheimer’s disease. Hanan.M. Ragab, Mohamed Teleb, Hassan R. Haidar and Noha Gouda, Global Experts Meeting on: Pharmaceutics And Novel Drug Delivery Systems, London, England, 15-17 July, 2019, p52.

9. Synthesis and Biological Evaluation of Some Heterocyclic Compounds as B-lactamase Inhibitors. Adnan Bekhit,Mona A. Mahran, Kenichi Akaji, Hanan.M. Ragab, Marwa M. Shaaban, Pharmaceutical and Health Sciences Conference, Faculty of Pharmacy, Alexandria, Egypt, 6-7 November, 2019, PHS216.

10. Synthesis of some novel heterocyclic compounds linked to or fused with phenolic or quinonoid moieties for potential biological activities. Haidy H. Mohamed, Ibrahim C. Ahmed, Hanan M. Ragab and Ahmed S. Belel, Pharmaceutical and Health Sciences Conference, Faculty of Pharmacy, Alexandria, Egypt, 6-7 November, 2019, PHS 222.

12. Investigation of the potential anti-inflammatory and analgesic activities of some chemical products. FadiHodeib, Hanan Ragab, 2019 ASHP Midyear Clinical Meeting, Las Vegas, NV, united states of America, 8-12 December, 2019, p320.

13. Novel Heterocyclic derivatives asmetallo-B-lactamase Inhibitors: A Milestone in Overcoming Antibiotic Resistance. Marwa M. Shaaban,Hanan.M. Ragab, Kenichi Akaji,Bassma H. Elwakil, Alaa-ELdin A. Bekhit, Waleed M. Hussein, Mona A. Mahran, Adnan Bekhit, , Second PUA International Conference on “Multidisciplinary Approaches in Pharmaceutical Sciences” ICMAPS 2020, Pharos University in Alexandria, Alexan