Assoc. Prof. Dr. Hanan Ragab

Associate Professor
Department of Medicinal Chemistry

Biography

Faculty Appointments:

  • Deputy of Quality Assurance Unit, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt.
  • Vice deputy, Quality Assurance Unit, Faculty of Pharmacy, University of Alexandria, Egypt.
  • 2019, Member of the organizing committee of PHS2019 conference, Faculty of Pharmacy, University of Alexandria, Egypt.
  • Head of clinical control, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt.

Areas of Expertise:

Research Activities (Faculty of Pharmacy at Alexandria University, Virginia commonwealth University and Beirut Arab University):

Design, synthesis and in vitro/in vivo evaluation of new pharmacologically active compounds including: Acetyl Cholinesterase Inhibitors, Nicotinic Receptor Ligands, Anti-inflammatory and analgesic drugs, Anticancer drugs, Antimicrobial agents and Antimalarial agents.

Teaching Activities (Faculty of Pharmacy at Alexandria University, Damanhur University, Arab Academy for Science, Technology & Maritime Transport, Kafr El Sheikh University and Beirut Arab University):

Teaching of Practical and Theoretical Pharmaceutical Organic Chemistry courses for undergraduate students as well as continuing education courses for medical professions and postgraduate courses.

  • 2019-present, Associate professor,Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt.
  • 2014 – 2019, Lecturer, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt.
  • 2011 – 2014, Assistant Professor, Department of Pharmaceutical Chemistry, Faculty of Pharmacy,  Beirut Arab University, Beirut 11072809, Lebanon.
  • 2007 – 2011, Lecturer, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria21521, Egypt.
  • 2003 – 2007, Assistant Lecturer, Department of Pharmaceutical Chemistry, Faculty of Pharmacy,  University of Alexandria, Alexandria21521, Egypt.
  • 2000 – 2003, Demonstrator (Teaching Assistant), Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria21521, Egypt
  • Deputy of Quality Assurance Unit, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt.
  • Vice deputy, Quality Assurance Unit, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt.
  • 2019, Member of the organizing committee of PHS2019 & PHS 2022 conference, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt.
  • Head of clinical control, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt.

Alexandria University:

  • Teaching of Practical and Theoretical Pharmaceutical Organic Chemistry courses for undergraduate students as well as continuing education courses for medical professions.
  • Teaching Spectroscopic Identification of Pharmaceutical Compounds course (0905601) for postgraduate “Drug Design, Synthesis & Quality Control” Diploma, Alexandria University, Egypt.
  • Teaching Selected Topics in Advanced Organic Chemistry Course (0905801) for postgraduate “Drug Design, Synthesis & Quality Control” Diploma, Alexandria University, Egypt.
  • Teaching Seminar I courses for postgraduate program students, Alexandria University, Egypt.

Beirut Arab University (2011-2014):

  • Teaching of Practical and Theoretical Pharmaceutical Organic Chemistry, Pharmaceutical Chemistry, Medicinal Chemistry courses for undergraduate students as well as continuing education courses for medical professions.
  • Teaching Theoretical course on Drug Library and Literature Surveying for postgraduate students.

College of Pharmacy, Arab Academy for Science, Technology & Maritime Transport (2016/2017):

  • Teaching of Practical and Theoretical Pharmaceutical Organic Chemistry courses for undergraduate students.

Faculty of Pharmacy, Damanhour University (2009-2011, 2014-2020)

  • Teaching of Practical and Theoretical Pharmaceutical Organic Chemistry courses for undergraduate students.

Faculty of Pharmacy, Kafr El Sheikh University (2019-2021)

  • Teaching of Practical and Theoretical Pharmaceutical Organic Chemistry courses for undergraduate students.
  • Teaching Selected Topics in Advanced Organic Chemistry Course for postgraduate students.

Faculty of Pharmacy, Alamein international University (2021/2022)

  • Teaching of Practical and Theoretical Pharmaceutical Organic Chemistry courses for undergraduate students.

1.Elucidation of the molecular mechanism underlying the anti-inflammatory activity of an effective and
safe bipyrazole-based compound. S Domiati, M Mehanna, H Ragab, KH Abd El Galil, HN Chmaisse, A
El Mallah, Inflammation Research, 68, 379(2019)

2. Chlorinated tacrine analogs: Design, synthesis and biological evaluation of their anti-cholinesterase
activity as potential treatment for Alzheimer’s disease. Hanan.M. Ragab, Mohamed Teleb, Hassan R.
Haidar and Noha Gouda, Bioorg. Chem, 86, 557-568 (2019).

3. Synthesis, biological evaluation and modeling of hybrids from tetrahydro-1H-pyrazolo[3,4-b]quinolines as dual cholinestrase and COX-2 inhibitors. Mohamed Mroueh, Wissam H. Faour, Wassim N. Shebaby, Costantine F. Daher, Tamer M. Ibrahim, Hanan M. Ragab, Bioorg. Chem, 100, 103895 (2020).

4. Design, synthesis, biological evaluation and in silico studies of certain aryl sulfonyl hydrazones
conjugated with 1,3-diaryl pyrazoles as potent metallo-β-lactamase inhibitors. Marwa M. Shaaban, Hanan M. Ragab, Kenichi Akaji, Ross P. McGeary, Alaa-Eldin A. Bekhit, Waleed M. Hussein, Julia L. Kurz, Bassma H. Elwakil, Salma A. Bekhit, Tamer M. Ibrahim, Mona A. Mahran, Adnan A. Bekhit. Bioorg. Chem, 105, 104386 (2020).

5. Targeting multiple conformations of SARS-CoV2 Papain-Like Protease for drug repositioning: An insilico study. Mohamed M. Ismail, Hanan M. Ragab, Adnan A. Bekhit, Tamer M. Ibrahim. Computers in biology and medicine, 131, 104295 (2021).

6. Design, Synthesis, and Anticancer Screening for Repurposed Pyrazolo[3,4-d]pyrimidine Derivatives on Four Mammalian Cancer Cell Lines. Eman M. Othman, Amany A. Bekhit, Mohamed A. Anany, Thomas Dandekar, Hanan M. Ragab and Ahmed Wahid. Molecules, 26, 2961(2021).

7. Transforming Iodoquinol into Broad Spectrum Anti-Tumor Leads: Repurposing to Modulate Redox
Homeostasis. Ibrahim Chaaban, Haidy Hafez, Ibrahim AlZaim, Cynthia Tannous, Hanan Ragab, Aly
Hazzaa, Salma Ketat, Asser Ghoneim, Mohamed Katary, Mohamed M. Abd-Alhaseeb, Fouad A. Zouein,
Amgad Albohy, Ahmed Noby Amer, Ahmed F. El-Yazbi, Ahmed S.F. Belal. Bioorg. Chem, 113, 105035
(2021).

8. Halting Colorectal Cancer Metastasis Via Novel Dual Nanomolar MMP-9/MAO-A Quinoxaline-Based Inhibitors; Design, Synthesis, And Evaluation. Mohammed Salah Ayoup, Marwa M. Abu-Serie, Laila F. Awad, Mohamed Teleb, Hanan M. Ragab, Adel Amer. Eur. J. Med Chem. 113558(2021).

9. Structure-guided approach on the role of substitution on amide-linked bipyrazoles and its effect on their anti-inflammatory activity. Souraya A. Domiati, Khaled H. Abd El Galil, Mohammed A.S. Abourehab, Tamer M. Ibrahim, Hanan M. Ragab, J Enz Inhib Med Chem, 37(1), 2179 (2022).

10. New pyrazolylpyrazoline derivatives as dual acting antimalaria-antileishmanial agents:
synthesis,biological evaluation and molecular modelling simulations. Adnan A Bekhit, Eskedar T
Lodebo, Ariaya Hymete, Hanan M Ragab, Salma A Bekhit, Kikuko Amagase, Afnan Batubara,
Mohammed AS Abourehab, Alaa El-Din A Bekhit, Tamer M Ibrahim, J Enz Inhib Med Chem, 37(1),
2320 (2022)

11.Molecular mechanics simulations and experimental investigation of the effect of tadalafil on various
inflammatory pain mediators. Souraya A. Domiati, Khaled H. Abd El Galil, Hanan M. Ragab, ACS
Omega, 48(7), 43747 (2022).

12. The Role of Pyrazolo[3,4-d]pyrimidine-Based Kinase Inhibitors in The Attenuation of CCl4-Induced Liver Fibrosis in Rats. Diana K. Ghobrial, Nefertiti El-Nikhely, Eman Sheta, Hanan M. Ragab, Sherif A. F. Rostom, Hesham Saeed and Ahmed Wahid, Antioxidants, 12(3), 637(2023).

1. Chlorinated tacrine analogs: Design, synthesis and biological evaluation of their anti-cholinesterase activity as potential treatment for Alzheimer’s disease. Hanan.M. Ragab, Mohamed Teleb, Hassan R. Haidar and Noha Gouda, Global Experts Meeting on: Pharmaceutics And Novel Drug Delivery Systems, London, England, 15-17 July, 2019, p52.

2. Synthesis and Biological Evaluation of Some Heterocyclic Compounds as -lactamase Inhibitors. Adnan Bekhit,Mona A. Mahran, Kenichi Akaji, Hanan.M. Ragab, Marwa M. Shaaban, Pharmaceutical and Health Sciences Conference (PHS), Faculty of Pharmacy, Alexandria, Egypt, 6-7 November, 2019, PHS216.

3. Synthesis of some novel heterocyclic compounds linked to or fused with phenolic or quinonoid moieties for potential biological activities. Haidy H. Mohamed, Ibrahim C. Ahmed, Hanan M. Ragab and Ahmed S.Belel, Pharmaceutical and Health Sciences Conference (PHS), Faculty of Pharmacy, Alexandria, Egypt, 6-7 November, 2019, PHS 222.

4. Investigation of the potential anti-inflammatory and analgesic activities of some chemical products. Fadi Hodeib, Hanan Ragab, 2019 ASHP Midyear Clinical Meeting, Las Vegas, NV, united states of America, 8-12 December, 2019, p320.

5. Novel Heterocyclic derivatives asmetallo--lactamase Inhibitors: A Milestone in Overcoming Antibiotic Resistance. Marwa M. Shaaban,Hanan.M. Ragab, Kenichi Akaji,Bassma H. Elwakil, Alaa-ELdin A. Bekhit, Waleed M. Hussein, Mona A. Mahran, Adnan Bekhit, , Second PUA International Conference on “Multidisciplinary Approaches in Pharmaceutical Sciences” ICMAPS 2020, Pharos University in Alexandria, Alexandria, Egypt, 11-12March, 2020, PC-P-06, p40.