Prof. Dr. Hayam Ashour

Professor
Department of Medicinal Chemistry

Biography

Dr. Hayam Ashour is a Professor of pharmaceutical chemistry, area of interest/medicinal chemistry, drug synthesis , drug design and organic chemistry

  • 1993-1998, Demonstrator of pharmaceutical chemistry, Faculty of pharmacy, Alexandria University, Egypt.
  • 1998-2002, Assistant lecturer of pharmaceutical chemistry, Faculty of pharmacy, Alexandria University, Egypt.
  • 2002-2009, Lecturer of pharmaceutical chemistry, Faculty of pharmacy, Alexandria University, Egypt.
  • 2009-2016, Associate Professor of pharmaceutical chemistry, Faculty of pharmacy, Alexandria University, Egypt.
  • 2017-present, Professor of pharmaceutical chemistry, Faculty of pharmacy, Alexandria University, Egypt.

Active member of Quality Assurance and Accreditation Project and Continuous Improvement and Qualifying for Accreditation Project CIQAP, Faculty of pharmacy, Alexandria University, Egypt.

  • Teaching the theoretical and practical courses of Pharmaceutical Organic Chemistry for the first and second year undergraduate students- Faculty of Pharmacy, Alexandria University, Damanhour University, Pharos University and Beirut Arab University.
  • Teaching the theoretical and practical courses of Pharmaceutical Organic Chemistry for undergraduate clinical program students, Faculty of Pharmacy, Alexandria University, Egypt.
  • Teaching theoretical advanced organic pharmaceutical chemistry courses and Drug Synthesis courses for postgraduate students : Drug Design, Synthesis, and Quality Control Diploma, Alexandria University, Egypt.
  • Teaching Seminar I courses for Ph.d. program students, Alexandria University, Egypt.

1. Synthesis and pharmacological evaluation of new pyrazolylbenzenesulfonamides linked to polysubstituted pyrazoles and thiazolidinones as antiinflammatory and analgesic agents, Monatsh Chem 2016, 147 ,605-618.

2. Novel 1,5-diphenyl-6-substituted 1H-pyrazolo (3,4-d) pyrimidin-4(5H)ones induced apoptosis in RKO colon cancer cells, J. Enzyme Inhib. Med. Chem., 2016, 31, 1286-1299.

3. Synthesis of some new amide linked bipyrazoles and their evaluation as antiinflammatory and analgesic agents, J. Enzyme Inhib. Med. Chem., 2016, 31, 1079-1094.

4. New 3-Cyano-2-substituted Pyridines Induce apoptosis in MCF7 breast cancer cells, Molecules 2016, 21, 230, doi:10.3390/molecules 21020230

5. Synthesis and biological evaluation of some tacrine analogs:Study of the effect of the chloro substituent on the acetylcholinesterase inhibitory activity, Monatsh Chem 2016, 147, 539-552.

6. Synthesis of new pyrazolo(3,4-d)pyrimidine derivatives and evaluation of their antiinflammatory and anticancer activities, Chem. Biol. Drug Des. 2017, 90, 83-96.

7. Target Identification, lead optimisation and antitumor evaluation of some new 1,2,4-triazines as c-met kinase inhibitors, Bioorg. Chem. 2017, 73, 154-169.

8. Structure-based development of novel triazoles and related thiazolotriazoles as anticancer agents and Cdc25A/B phosphatase inhibitors. Synthesis, invitro biological evaluation, molecular docking and in silico ADME-T studies, EUR. J. Med. Chem. 2017, 139, 263-279.

9. Design, Synthesis and molecular modelling studies of new series of antitumor 1,2,4-triazines with potential c-Met kinase inhibitory activity, Bioorg. Chem. 2018, 76, 154-165.

10. Design, Synthesis and evaluation of some pyrazolo (3,4-d)pyrimidines as antiinflammatory agents, Bioorg. Chem. 2018, 78, 358-371.

11. Design, synthesis and evaluation of some pyrazolo (3,4-d) pyrimidine derivatives bearing thiazolidinone moiety as antiinflammatory agents, Bioorg. Chem. 2018, 80, 164-173.

12. Design and Synthesis of novel thioethers derived from 1,5-diphenyl-6-thioxo-6,7-dihydro-1H-pyrazolo(3,4-d) pyrimidin-4 (5H)-ones as antiangiogenic agents, Lett. Drug Disc. Des. 2018, 16, 200-212.

13. Potential anticancer agents: Design, synthesis of new pyrido(1,2-a) benzimidazoles and related derivatives linked to alkylating fragments, Med. Chem 2018, 8(4): 86, DOI: 10.4172/2161-0444.1000498

14. Synthesis, modelling and biological evaluation of some pyrazolo (3,4-d)pyrimidinones and pyrazolo(4,3-e)(1,2,4)triazolo(4,3-a) pyrimidinones as antiinflammatory agents, Bioorg. Chem. 2019, 90, 102844.
15. Discovery of a novel DNA binding agent via design and synthesis of new thiazole hybrids and fused 1,2,4-triazines as potential antitumor agents: Computational, spectrometric and in silico studies, Bioorg. Chem. 2019, 90, 103089.

1. The Fourth Pharmaceutical Sciences Conference, Faculty of Pharmacy, Assiut University, Assiut, March 6-7, 2004. Poster presentation entitled: Novel pyrazole derivatives as potential promising antiinflammatory antimicrobial agents, A. A. Bekhit, Hayam M.A. Ashour and A.A. Guemei.

2. The sixth AFMC International Medicinal Chemistry Symposium, Istanbul, Turkey, 8-11 July 2007. Poster presentation entitled: Design and synthesis of novel substituted tetrazoles as a new class of antifungal agents, Heba A. Abdel Razik, Sherif A. F. Rostom, Hayam M.A. Ashour.

3. The sixth AFMC International Medicinal Chemistry Symposium, Istanbul, Turkey, 8-11 July, 2007. Poster presentation entitled: Synthesis and biological evaluation of novel pyrazole derivatives as antiinflammatory antimicrobial agents, Adnan A. Bekhit, Hayam M.A. Ashour, Alaa E. A. Bekhit and Salma A. Bekhit.

4. The 11th Ibn Sina International Conference on Pure and Applied Heterocyclic Chemistry (ISIC), Cairo, December 13-16, 2008. Poster presentation entitled: Synthesis and biological evaluation of novel pyrimidines with anticipated antimicrobial and anticancer activities, Heba A. Abdel Razik, Sherif A. F. Rostom, Hayam M.A. Ashour.

5. The World Congress of Pharmacy and Pharmaceutical Sciences, 68th International Congress of FTP (Reengineering Pharmacy Practice in a Changing World), Basel, Switzerland, August 29th -September 4th, 2008. Poster presentation entitled: Design and synthesis of some thiadiazolyl antipyrine derivatives with anticipated dual antiinflammatory antimicrobial activity, Mona H. Badr, Sherif A. F. Rostom, Hayam M.A. Ashour, Heba A. Abdel Razik.

6. The 11th Ibn Sina International Conference on Pure and Applied Heterocyclic Chemistry, Cairo, December 13-16, 2008. Poster presentation entitled: Synthesis and biological evaluation of novel pyrazoles and pyrazolo (3,4-d) pyrimidines incorporating benzene sulfonamide moiety, Hayam M.A. Ashour and Abeer E. Abdel Wahab.

7. The 3rd International IUPAC Conference on Green Chemistry, Ottawa, Canada, 15-18 August 2010. Poster presentation entitled: Synthesis of certain polymethoxylated chalcones and some derived heterocyclic ring systems with anticipated anticancer and antimicrobial activities, Mona H. Badr, Hayam M.A. Ashour, Heba A. Abdel Razik, Sherif A. F. Rostom.

8. The 1st International Conference on Science Diplomacy and Development in Chemistry, Alexandria, Egypt, 24-26 November 2012. Poster presentation entitled: Synthesis and pharmacological evaluation of some 4-(5-amino-4-substituted 1H-pyrazole-1-yl) benzene sulfonamide derivatives as antiinflammatory agents, Hayam M.A. Ashour.

9. The 3rd International Conference on Organic Chemistry (ICOC-2014) Organic Synthesis-Driving Force of Life Development, Tbilisi, Georgia, 25-28 September, 2014. Two poster presentation entitled: Synthesis of some new amide linked bipyrazoles and their evaluation as antiinflammatory, analgesic and antimicrobial agents, Hayam M.A. Ashour, Rasha Y. Elbayaa, Hanan M. Ragan, Asset I. Ghoneim, Mohamed Mroueh, Wissam Favour.
Novel 1,5-diphenyl-6-substituted pyrazolo (3,4-d) pyrimidin-4-ones induced apoptosis in colon cancer RKO cells via targeting mitochondrial pathway, Ahmed Malki, Hayam M.A. Ashour, Doaa A. E. Issa, Rasha Y. Elbayaa, Hassan A. Aziz, Xiaozhuo Chen.

10. First International Conference on Applied Chemistry (ICAC 2015), Jeddah, Kingdom of Saudi Arabia, 18-19 November 2015. Poster presentation entitled: Novel 3-cyano-2-substituted pyridines induced apoptosis in human MCF-7 breast cancer cells, Ahmed Malki, Omaima Shaban, Ola Rizk, Hayam Ashour.

11. ICPCB 2017: 19th International Conference on Medicinal Chemistry and Biopharmaceutical, London, England, 19-20 January. Poster presentation entitled: Design, synthesis and evaluation of some pyrazolo (3,4-d) pyrimidines as antiinflammatory agents, Gina N. Tageldin, Salwa M. Fahmy, Hayam M.A. Ashour, Mounir A. Khalil, Rasha A. Nassra, Ibrahim M. Labours.